FOG17002
EOG86T1H9

sce:VPS27

Genes: 32

SGD Description
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)


PomBase Description
sorting receptor for ubiquitinated membrane proteins, ESCRT 0 complex subunit Sst4


AspGD Description
Ortholog(s) have ubiquitin binding activity and role in ascospore-type prospore assembly, endocytosis, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway


References

Robinson JS, et al. (1988 Nov). Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

Raymond CK, et al. (1992 Dec). Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

Piper RC, et al. (1995 Nov). VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

Nothwehr SF, et al. (1996 Jun). The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins.

Luo Wj, et al. (1997 Aug 25). Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant.

Bryant NJ, et al. (1997 Jan 27). Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention.

Burd CG, et al. (1998 Jul). Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains.

Misra S, et al. (1999 May 28). Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p.

Gerrard SR, et al. (2000 Mar). Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment.

Dupré S, et al. (2001 Jul). Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase.

Prescianotto-Baschong C, et al. (2002 Jan). Ordering of compartments in the yeast endocytic pathway.

Bilodeau PS, et al. (2002 Jul). The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

Stahelin RV, et al. (2002 Jul 19). Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

Shih SC, et al. (2002 May). Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis.

Fisher RD, et al. (2003 Aug 1). Structure and ubiquitin binding of the ubiquitin-interacting motif.

Katzmann DJ, et al. (2003 Aug 4). Vps27 recruits ESCRT machinery to endosomes during MVB sorting.

Diraviyam K, et al. (2003 May 2). Computer modeling of the membrane interaction of FYVE domains.

Bilodeau PS, et al. (2003 Oct 27). Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.

Swanson KA, et al. (2003 Sep 15). Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation.

Parrish WR, et al. (2004 Aug). Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.

Eugster A, et al. (2004 Jul). Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body.

Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Eguez L, et al. (2004 May). Yeast Mn2+ transporter, Smf1p, is regulated by ubiquitin-dependent vacuolar protein sorting.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Curtiss M, et al. (2007 Feb). Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12.

Gabriely G, et al. (2007 Jan). Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast.

Kama R, et al. (2007 Jan). Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast.

Calcagno-Pizarelli AM, et al. (2011 Dec 1). Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling.

Galindo A, et al. (2012 Apr 1). An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%