FOG16999
EOG86T1HP

sce:POP2

Genes: 31

SGD Description
RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation


PomBase Description
CCR4-Not complex CAF1 family ribonuclease subunit Caf1


References

Sakai A, et al. (1992 Dec 11). Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae.

Draper MP, et al. (1995 Jul). Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.

Liu HY, et al. (1998 Feb 16). The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.

Bai Y, et al. (1999 Oct). The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.

Chen J, et al. (2001 Dec 7). Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.

Tucker M, et al. (2001 Feb 9). The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.

Daugeron MC, et al. (2001 Jun 15). The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation.

Moriya H, et al. (2001 May 15). Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal.

Thore S, et al. (2003 Dec). X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex.

Morozov IY, et al. (2010 Apr). Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans.

Morozov IY, et al. (2010 Jan). CUCU modification of mRNA promotes decapping and transcript degradation in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%