FOG16944
EOG86WWVV

sce:RRS1

Genes: 33

SGD Description
Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice


PomBase Description
ribosome biogenesis protein Rrs1


AspGD Description
Ortholog(s) have single-stranded RNA binding activity


References

Tsuno A, et al. (2000 Mar). RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.

Asano N, et al. (2014 Dec 1). Crystallization and preliminary X-ray crystallographic analysis of ribosome assembly factors: the Rpf2-Rrs1 complex.

Kharde S, et al. (2015 Aug 18). The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis.

Asano N, et al. (2015 May 19). Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%