FOG16916
EOG870S1M

sce:MSS1

Genes: 33

SGD Description
Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3


PomBase Description
mitochondrial GTPase (predicted)


AspGD Description
Ortholog(s) have role in mitochondrial tRNA wobble uridine modification and mitochondrial inner membrane localization


References

Decoster E, et al. (1993 Jul 5). MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase.

Colby G, et al. (1998 Oct 23). MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae.

Umeda N, et al. (2005 Jan 14). Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.

Zuin A, et al. (2008 Jul 30). Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Hu L, et al. (2016 Aug). Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%