FOG16855
EOG876HHF

sce:CDC73

Genes: 33

SGD Description
Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homologue, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers


PomBase Description
RNA polymerase II accessory factor, Cdc73 family (predicted)


AspGD Description
Ortholog(s) have RNA polymerase II C-terminal domain phosphoserine binding, RNA polymerase II core binding, chromatin binding, transcription factor activity, TFIIF-class transcription factor binding activity


References

Shi X, et al. (1997 Mar). Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme.

Koch C, et al. (1999 May 15). A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast.

Mueller CL, et al. (2002 Apr). Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex.

Krogan NJ, et al. (2002 Oct). RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.

Porter SE, et al. (2005 Jan). Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization.

Sheldon KE, et al. (2005 Oct 28). A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%