FOG16783
EOG87D812

sce:RAD10

Genes: 32

SGD Description
Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein


PomBase Description
DNA repair endonuclease non-catalytic subunit Swi10


AspGD Description
Ortholog(s) have polyubiquitin binding activity and role in double-strand break repair via single-strand annealing, removal of nonhomologous ends, nucleotide-excision repair, response to UV


References

Gutz H, et al. (1985). Switching genes in Schizosaccharomyces pombe.

Reynolds P, et al. (1985 Dec 16). Nucleotide sequence of the RAD10 gene of Saccharomyces cerevisiae.

Weiss WA, et al. (1985 Jun). Molecular cloning and characterization of the yeast RAD10 gene and expression of RAD10 protein in E. coli.

Schmidt H, et al. (1989 Aug). Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage.

Rödel C, et al. (1992 Dec 11). The protein sequence and some intron positions are conserved between the switching gene swi10 of Schizosaccharomyces pombe and the human excision repair gene ERCC1.

Tomkinson AE, et al. (1993 Apr 29). Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease.

Carr AM, et al. (1994 Mar). The rad16 gene of Schizosaccharomyces pombe: a homolog of the RAD1 gene of Saccharomyces cerevisiae.

Guzder SN, et al. (1996 Apr 12). Nucleotide excision repair in yeast is mediated by sequential assembly of repair factors and not by a pre-assembled repairosome.

Hang H, et al. (1996 Apr 17). Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/radioresistance gene that shares sequence homology with human and mouse ERCC1.

Rödel C, et al. (1997 Jul 15). Complementation of the DNA repair-deficient swi10 mutant of fission yeast by the human ERCC1 gene.

Fleck O, et al. (1999 Mar). Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair.

Osman F, et al. (2000 Oct). The genetic control of spontaneous and UV-induced mitotic intrachromosomal recombination in the fission yeast Schizosaccharomyces pombe.

Boddy MN, et al. (2001 Nov 16). Mus81-Eme1 are essential components of a Holliday junction resolvase.

Wilkinson CR, et al. (2001 Oct). Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.

Kunz C, et al. (2001 Oct 19). Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction.

Osman F, et al. (2003 Apr). A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage.

Marti TM, et al. (2003 Jun). Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.

Kunz C, et al. (2003 Jun 1). Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Holmberg C, et al. (2005 Apr 1). Ddb1 controls genome stability and meiosis in fission yeast.

Lee KM, et al. (2007 Apr). Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.

Suter B, et al. (2007 Dec). Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system.

Xin F, et al. (2008 Apr 18). Molecular identification and characterization of peptide: N-glycanase from Schizosaccharomyces pombe.

Roseaulin L, et al. (2008 May 7). Mus81 is essential for sister chromatid recombination at broken replication forks.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Willis N, et al. (2009 Feb). Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Hänzelmann P, et al. (2010 Jun 25). The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.

Cavero S, et al. (2010 Sep 23). Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Heideker J, et al. (2011 Mar). SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Latypov VF, et al. (2012 Jul 13). Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

Yu Y, et al. (2013 Jun 1). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Zhang JM, et al. (2014 Sep). Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.

Wang H, et al. (2015 Jun). A novel protein, Rsf1/Pxd1, is critical for the single-strand annealing pathway of double-strand break repair in Schizosaccharomyces pombe.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Noguchi C, et al. (2017 Jan 2). Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%