FOG16731
EOG87M0CT

sce:APC2

Genes: 31

SGD Description
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p


PomBase Description
anaphase-promoting complex cullin family subunit Apc2


AspGD Description
Ortholog(s) have anaphase-promoting complex, cytosol localization


References

Zachariae W, et al. (1998 Feb 20). Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

Zheng N, et al. (2002 Apr 18). Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

Yoon HJ, et al. (2002 Dec 10). Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.

Schwickart M, et al. (2004 Apr). Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.

Zhang Z, et al. (2005). Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.

Yoon HJ, et al. (2006 Oct 27). Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.

Ohi MD, et al. (2007 Dec 14). Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.

Kimata Y, et al. (2008 Apr 1). Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.

Sczaniecka M, et al. (2008 Aug 22). The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%