FOG16711
EOG87M0H6

sce:GCG1

Genes: 32

SGD Description
Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle


PomBase Description
glutathione-specific gamma-glutamylcyclotransferase Ggg1 (predicted)


AspGD Description
Ortholog(s) have gamma-glutamylcyclotransferase activity, role in glutathione catabolic process and cytosol, nucleus localization


References

Samuelsen CO, et al. (2003 May 27). TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Kumar A, et al. (2012 Dec). Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Kaur A, et al. (2017 Jan 13). ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%