FOG16558
EOG883BKC

sce:ESP1

Genes: 34

SGD Description
Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress


PomBase Description
separase/separin


AspGD Description
Ortholog(s) have role in mitotic nuclear division, mitotic spindle organization


References

McGrew JT, et al. (1992 Dec). Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae.

Ciosk R, et al. (1998 Jun 12). An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.

Uhlmann F, et al. (1999 Jul 1). Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1.

Jensen S, et al. (2001 Jan 8). A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1.

Stegmeier F, et al. (2002 Jan 25). Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 19 genes with posterior transmembrane prediction > 50%