FOG16449
EOG88CZ9B

sce:SSL2

Genes: 33

SGD Description
Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to the cytosol in response to hypoxia; homolog of human ERCC3


PomBase Description
transcription factor TFIIH complex ERCC-3 subunit Ptr8


AspGD Description
Ortholog(s) have role in transcription initiation from RNA polymerase II promoter and nucleus localization


References

Park E, et al. (1992 Dec 1). RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability.

Gulyas KD, et al. (1992 Jun 12). SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3.

Svejstrup JQ, et al. (1994 Nov 11). RNA polymerase transcription factor IIH holoenzyme from yeast.

Sung P, et al. (1996 May 3). Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair.

Spahr H, et al. (2003 Dec 19). Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.

Takagi Y, et al. (2003 Nov 7). Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Tamayo E, et al. (2004 Jun). Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.

Lin YC, et al. (2005 Jul). TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape.

Mizuki F, et al. (2007 Jan). Participation of XPB/Ptr8p, a component of TFIIH, in nucleocytoplasmic transport of mRNA in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%