FOG16434
EOG88CZCV

sce:UBX2

Genes: 21

SGD Description
Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis


References

Schuberth C, et al. (2004 Aug). Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation.

Neuber O, et al. (2005 Oct). Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Schuberth C, et al. (2005 Oct). Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

Carvalho P, et al. (2006 Jul 28). Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%