FOG16289
EOG88SF86

sce:CTF4

Genes: 34

SGD Description
Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion


PomBase Description
DNA polymerase alpha accessory factor Mcl1


AspGD Description
Ortholog(s) have role in DNA repair, Okazaki fragment processing involved in mitotic DNA replication, cell septum assembly, chromatin silencing at centromere central core, chromosome segregation, conidium formation


References

Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.

Kouprina N, et al. (1992 Dec). CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae.

Miles J, et al. (1992 Dec). Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.

Kuprina NIu, et al. (1993 May-Jun). [CHL15--a new gene controlling the replication of chromosomes in saccharomycetes yeast: cloning, physical mapping, sequencing, and sequence analysis].

Harris SD, et al. (1994 Feb). Identification and characterization of Aspergillus nidulans mutants defective in cytokinesis.

Harris SD, et al. (1995 Nov 1). sepB: an Aspergillus nidulans gene involved in chromosome segregation and the initiation of cytokinesis.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Harris SD, et al. (1998 Mar). Regulation of septum formation in Aspergillus nidulans by a DNA damage checkpoint pathway.

Hofmann AF, et al. (2000 Apr). The Aspergillus nidulans uvsB gene encodes an ATM-related kinase required for multiple facets of the DNA damage response.

Williams DR, et al. (2002 Oct). mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.

Gygax SE, et al. (2005 Mar). SepBCTF4 is required for the formation of DNA-damage-induced UvsCRAD51 foci in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%