FOG16229
EOG88W9NG

sce:ATG8

Genes: 34

SGD Description
Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis


PomBase Description
autophagy associated protein Atg8


AspGD Description
Putative autophagy-related ubiquitin modifier; autophagosomal membrane protein; essential for autophagy


References

Tsukada M, et al. (1993 Oct 25). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Harding TM, et al. (1995 Nov). Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.

Lang T, et al. (1998 Jul 1). Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole.

Kirisako T, et al. (1999 Oct 18). Formation process of autophagosome is traced with Apg8/Aut7p in yeast.

Huang WP, et al. (2000 Feb 25). The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways.

Ichimura Y, et al. (2000 Nov 23). A ubiquitin-like system mediates protein lipidation.

Kirisako T, et al. (2000 Oct 16). The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway.

Legesse-Miller A, et al. (2000 Oct 20). Aut7p, a soluble autophagic factor, participates in multiple membrane trafficking processes.

Kim J, et al. (2001 Jan 8). Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex.

Komatsu M, et al. (2001 Mar 30). The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation.

Suzuki K, et al. (2001 Nov 1). The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.

Shintani T, et al. (2002 Dec). Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway.

Kim J, et al. (2002 Jan 4). Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation.

Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Strømhaug PE, et al. (2004 Aug). Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.

Suzuki K, et al. (2004 Sep). Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae.

Ichimura Y, et al. (2004 Sep 24). In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy.

Meiling-Wesse K, et al. (2004 Sep 3). Atg21 is required for effective recruitment of Atg8 to the preautophagosomal structure during the Cvt pathway.

Yorimitsu T, et al. (2005 Apr). Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway.

Reggiori F, et al. (2005 Dec). The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae.

Meiling-Wesse K, et al. (2005 Sep 30). Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.

Amar N, et al. (2006 Jun). Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.

Bernales S, et al. (2006 Nov). Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response.

Kohda TA, et al. (2007 Feb). Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.

Suzuki K, et al. (2007 Feb). Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Nakatogawa H, et al. (2007 Jul 13). Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.

Zhang Y, et al. (2007 Jul-Aug). The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains.

Ma J, et al. (2007 Nov-Dec). Overexpression of autophagy-related genes inhibits yeast filamentous growth.

Yorimitsu T, et al. (2007 Oct). Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae.

Xie Z, et al. (2008 Aug). Atg8 controls phagophore expansion during autophagosome formation.

Cao Y, et al. (2008 Aug 25). In vivo reconstitution of autophagy in Saccharomyces cerevisiae.

Noda NN, et al. (2008 Dec). Structural basis of target recognition by Atg8/LC3 during selective autophagy.

Cheong H, et al. (2008 Feb). The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.

Geng J, et al. (2008 Jul 14). Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Hanada T, et al. (2009 Apr 2). The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation.

Mukaiyama H, et al. (2009 Dec). Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.

Xie Z, et al. (2009 Feb). Indirect estimation of the area density of Atg8 on the phagophore.

Okamoto K, et al. (2009 Jul). Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.

Ho KH, et al. (2009 May). Mutation at the cargo-receptor binding site of Atg8 also affects its general autophagy regulation function.

Nair U, et al. (2010 Apr 9). Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.

Mendes-Ferreira A, et al. (2010 Dec). Accumulation of non-superoxide anion reactive oxygen species mediates nitrogen-limited alcoholic fermentation by Saccharomyces cerevisiae.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Yen WL, et al. (2010 Jan 11). The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.

Kumeta H, et al. (2010 Jul). The NMR structure of the autophagy-related protein Atg8.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Mikawa T, et al. (2010 Mar). Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance.

Schwarten M, et al. (2010 May 7). Solution structure of Atg8 reveals conformational polymorphism of the N-terminal domain.

Yamaguchi M, et al. (2010 Sep 17). Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.

Krick R, et al. (2010 Sep 20). Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8.

Mari M, et al. (2010 Sep 20). An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis.

Suzuki K, et al. (2010 Sep 24). Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p.

Mendl N, et al. (2011 Apr 15). Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.

Bruns C, et al. (2011 Dec 12). Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion.

Noda NN, et al. (2011 Nov 4). Structural basis of Atg8 activation by a homodimeric E1, Atg7.

Hong SB, et al. (2011 Nov 6). Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.

Mijaljica D, et al. (2012). A late form of nucleophagy in Saccharomyces cerevisiae.

Yi C, et al. (2012 Apr 27). Function and molecular mechanism of acetylation in autophagy regulation.

Nakatogawa H, et al. (2012 Aug 17). The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.

Nakatogawa H, et al. (2012 Feb 1). Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.

Nobile CJ, et al. (2012 Jan 20). A recently evolved transcriptional network controls biofilm development in Candida albicans.

Bartholomew CR, et al. (2012 Jul 10). Ume6 transcription factor is part of a signaling cascade that regulates autophagy.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Yu ZQ, et al. (2012 Jun). Dual roles of Atg8-PE deconjugation by Atg4 in autophagy.

Kondo-Okamoto N, et al. (2012 Mar 23). Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.

Nair U, et al. (2012 May 1). A role for Atg8-PE deconjugation in autophagosome biogenesis.

Romanov J, et al. (2012 Nov 14). Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.

Kraft C, et al. (2012 Sep 12). Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Suzuki K, et al. (2013 Jun 1). Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Su Y, et al. (2015). Schizosaccharomyces pombe Homologs of Human DJ-1 Are Stationary Phase-Associated Proteins That Are Involved in Autophagy and Oxidative Stress Resistance.

Katz ME, et al. (2015 Oct). Distinct roles for the p53-like transcription factor XprG and autophagy genes in the response to starvation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%