FOG16173
EOG893208

sce:DOT1

Genes: 31

SGD Description
Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response


AspGD Description
Ortholog(s) have histone methyltransferase activity (H3-K79 specific), nucleosomal histone binding activity


References

Singer MS, et al. (1998 Oct). Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.

San-Segundo PA, et al. (2000 Oct). Role for the silencing protein Dot1 in meiotic checkpoint control.

Briggs SD, et al. (2002 Aug 1). Gene silencing: trans-histone regulatory pathway in chromatin.

Lacoste N, et al. (2002 Aug 23). Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

van Leeuwen F, et al. (2002 Jun 14). Dot1p modulates silencing in yeast by methylation of the nucleosome core.

Ng HH, et al. (2002 Jun 15). Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.

Ng HH, et al. (2002 Sep 20). Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

Ng HH, et al. (2003 Feb 18). Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.

Sawada K, et al. (2004 Oct 8). Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase.

Giannattasio M, et al. (2005 Mar 18). The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

Wysocki R, et al. (2005 Oct). Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%