FOG16127
EOG895X7B

sce:PSO2

Genes: 31

SGD Description
Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress


PomBase Description
DNA 5' exonuclease (predicted)


AspGD Description
Ortholog(s) have 5'-3' exonuclease activity, damaged DNA binding activity, role in interstrand cross-link repair and nucleus localization


References

Richter D, et al. (1992 Jan). Molecular structure of the DNA cross-link repair gene SNM1 (PSO2) of the yeast Saccharomyces cerevisiae.

Niegemann E, et al. (1994 Nov). A single amino acid change in SNM1-encoded protein leads to thermoconditional deficiency for DNA cross-link repair in Saccharomyces cerevisiae.

Wolter R, et al. (1996 Feb 5). Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-links.

Grossmann KF, et al. (2000 Sep 15). Saccharomyces cerevisiae lacking Snm1, Rev3 or Rad51 have a normal S-phase but arrest permanently in G2 after cisplatin treatment.

Grossmann KF, et al. (2001 Dec 19). S. cerevisiae has three pathways for DNA interstrand crosslink repair.

Callebaut I, et al. (2002 Aug 15). Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family.

Li X, et al. (2003 Jan 2). The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiae.

Yu J, et al. (2004 Feb). Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae.

Li X, et al. (2005 Feb 3). The yeast Snm1 protein is a DNA 5'-exonuclease.

Barber LJ, et al. (2005 Mar). DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%