FOG16016
EOG89GHZ8

sce:RSC1;RSC2

Genes: 35

SGD Description
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication|Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication


PomBase Description
RSC complex subunit Rsc1


AspGD Description
Ortholog(s) have DNA translocase activity


References

Cairns BR, et al. (1996 Dec 27). RSC, an essential, abundant chromatin-remodeling complex.

Lorch Y, et al. (1999 Feb 5). Histone octamer transfer by a chromatin-remodeling complex.

Moreira JM, et al. (1999 May 17). Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC.

Cairns BR, et al. (1999 Nov). Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains.

Saha A, et al. (2002 Aug 15). Chromatin remodeling by RSC involves ATP-dependent DNA translocation.

Chai B, et al. (2002 Jun). Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway.

Wong MC, et al. (2002 Jun). RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae.

Yukawa M, et al. (2002 May). Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process.

Hsu JM, et al. (2003 May). The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Monahan BJ, et al. (2008 Aug). Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Garcia JF, et al. (2010 Aug 15). Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.

Buttrick GJ, et al. (2011 Dec). Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%