FOG15935
EOG89P8FG

sce:REF2

Genes: 5

SGD Description
RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; relocalizes to the cytosol in response to hypoxia


References

Russnak R, et al. (1995 Mar). REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation.

Russnak R, et al. (1996). RNA binding analysis of yeast REF2 and its two-hybrid interaction with a new gene product, FIR1.

Nedea E, et al. (2003 Aug 29). Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.

Dheur S, et al. (2003 Jun 2). Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation.

Mangus DA, et al. (2004 May). Identification of factors regulating poly(A) tail synthesis and maturation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%