FOG15892
EOG89S4Q6

sce:FCP1

Genes: 33

SGD Description
Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia


PomBase Description
CTD phosphatase Fcp1


AspGD Description
Ortholog(s) have CTD phosphatase activity and role in dephosphorylation of RNA polymerase II C-terminal domain, negative regulation of G0 to G1 transition, regulation of mitotic cytokinesis


References

Chambers RS, et al. (1996 Oct 4). Purification and characterization of an RNA polymerase II phosphatase from yeast.

Kobor MS, et al. (1999 Jul). An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

Hausmann S, et al. (2002 Jun 14). Characterization of the CTD phosphatase Fcp1 from fission yeast. Preferential dephosphorylation of serine 2 versus serine 5.

Kimura M, et al. (2002 Mar). Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol II.

Hausmann S, et al. (2003 Apr 18). Defining the active site of Schizosaccharomyces pombe C-terminal domain phosphatase Fcp1.

Kimura M, et al. (2004). Tfg3, a subunit of the general transcription factor TFIIF in Schizosaccharomyces pombe, functions under stress conditions.

Hausmann S, et al. (2004 Mar 19). Schizosaccharomyces pombe carboxyl-terminal domain (CTD) phosphatase Fcp1: distributive mechanism, minimal CTD substrate, and active site mapping.

Galagan JE, et al. (2005 Dec 22). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Mitsuzawa H, et al. (2005 Jan 3). Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit.

Karagiannis J, et al. (2007 May 9). A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.

Sukegawa Y, et al. (2011 Dec). The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Schwer B, et al. (2015 Jun). Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%