FOG15887
EOG89S4RC

sce:SCO1;SCO2

Genes: 33

SGD Description
Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication|Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication


PomBase Description
copper chaperone Sco1 (predicted)


AspGD Description
Ortholog(s) have copper ion binding activity, role in copper ion transport, protein complex assembly and mitochondrial inner membrane, plasma membrane localization


References

Schulze M, et al. (1989 Mar). Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane-associated protein, encoded by the nuclear SCO1 gene.

Buchwald P, et al. (1991 Oct). Immunological identification of yeast SCO1 protein as a component of the inner mitochondrial membrane.

Abajian C, et al. (2006 Jun). Crystal structure of yeast Sco1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%