FOG15865
EOG89W0XG

sce:YLH47;MDM38

Genes: 46

SGD Description
Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome|Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome


PomBase Description
mitochondrial inner membrane protein involved in potassium ion transport Mdm28 (predicted)


AspGD Description
Ortholog(s) have mitochondrion, plasma membrane localization


References

Waldherr M, et al. (1993 Oct). A multitude of suppressors of group II intron-splicing defects in yeast.

Dimmer KS, et al. (2002 Mar). Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Nowikovsky K, et al. (2004 Jul 16). The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.

Frazier AE, et al. (2006 Feb 13). Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.

Bauerschmitt H, et al. (2010 Jun 15). Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation.

Lupo D, et al. (2011 Oct). Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 45 genes with posterior transmembrane prediction > 50%