FOG15756
EOG8B5MKX

sce:DYN1

Genes: 31

SGD Description
Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p


PomBase Description
minus-end directed microtubule motor, dynein heavy chain Dhc1


AspGD Description
Ortholog(s) have ATP-dependent microtubule motor activity, minus-end-directed, microtubule binding, minus-end directed microfilament motor activity


References

Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.

Doonan JH, et al. (1992 Nov). Cell division in Aspergillus.

Eshel D, et al. (1993 Dec 1). Cytoplasmic dynein is required for normal nuclear segregation in yeast.

Li YY, et al. (1993 Nov 1). Disruption of mitotic spindle orientation in a yeast dynein mutant.

Xiang X, et al. (1994 Mar 15). Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans.

Xiang X, et al. (1995). Analysis of nuclear migration in Aspergillus nidulans.

Willins DA, et al. (1995 Dec). An alpha tubulin mutation suppresses nuclear migration mutations in Aspergillus nidulans.

Morris NR, et al. (1995 Jul). Nuclear migration advances in fungi.

Goldman GH, et al. (1995 Mar). Extragenic suppressors of a dynein mutation that blocks nuclear migration in Aspergillus nidulans.

Chiu YH, et al. (1995 Oct). Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.

Xiang X, et al. (1995 Oct 10). Characterization and localization of the cytoplasmic dynein heavy chain in Aspergillus nidulans.

Wolkow TD, et al. (1996 Aug). Cytokinesis in Aspergillus nidulans is controlled by cell size, nuclear positioning and mitosis.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Willins DA, et al. (1997 Jun). Mutations in the heavy chain of cytoplasmic dynein suppress the nudF nuclear migration mutation of Aspergillus nidulans.

Chiu YH, et al. (1997 Sep). Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal.

Inoue S, et al. (1998 Jun). Role of fungal dynein in hyphal growth, microtubule organization, spindle pole body motility and nuclear migration.

Efimov VP, et al. (1998 May). A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosis.

Beckwith SM, et al. (1998 Nov 30). The "8-kD" cytoplasmic dynein light chain is required for nuclear migration and for dynein heavy chain localization in Aspergillus nidulans.

Fischer R, et al. (1999 Jan). Nuclear movement in filamentous fungi.

Liu B, et al. (2000 Apr). A spindle pole body-associated protein, SNAD, affects septation and conidiation in Aspergillus nidulans.

Efimov VP, et al. (2000 Aug 7). The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein.

Suelmann R, et al. (2000 May). Nuclear migration in fungi--different motors at work.

Xiang X, et al. (2000 May 18). Dynamics of cytoplasmic dynein in living cells and the effect of a mutation in the dynactin complex actin-related protein Arp1.

Alberti-Segui C, et al. (2001 Mar). Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii.

Han G, et al. (2001 May 1). The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics.

Requena N, et al. (2001 Oct). Genetic evidence for a microtubule-destabilizing effect of conventional kinesin and analysis of its consequences for the control of nuclear distribution in Aspergillus nidulans.

Zhang J, et al. (2002 Apr). Cytoplasmic dynein intermediate chain and heavy chain are dependent upon each other for microtubule end localization in Aspergillus nidulans.

Zhang J, et al. (2003 Apr). Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent.

Liu B, et al. (2003 Jan). The requirement of the LC8 dynein light chain for nuclear migration and septum positioning is temperature dependent in Aspergillus nidulans.

Efimov VP, et al. (2003 Mar). Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects.

Xiang X, et al. (2004 Apr). Nuclear migration and positioning in filamentous fungi.

Li S, et al. (2005 Aug). Cytoplasmic dynein's mitotic spindle pole localization requires a functional anaphase-promoting complex, gamma-tubulin, and NUDF/LIS1 in Aspergillus nidulans.

Veith D, et al. (2005 Aug 15). Role of the spindle-pole-body protein ApsB and the cortex protein ApsA in microtubule organization and nuclear migration in Aspergillus nidulans.

Galagan JE, et al. (2005 Dec 22). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.

Konzack S, et al. (2005 Feb). The role of the kinesin motor KipA in microtubule organization and polarized growth of Aspergillus nidulans.

Lee WL, et al. (2005 Jan 17). The offloading model for dynein function: differential function of motor subunits.

Efimov VP, et al. (2006 Apr). CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans.

Johns SA, et al. (2006 Jun). Depletion of Aspergillus nidulans cotA causes a severe polarity defect which is not suppressed by the nuclear migration mutation nudA2.

Enke C, et al. (2007 Mar). Aspergillus nidulans Dis1/XMAP215 protein AlpA localizes to spindle pole bodies and microtubule plus ends and contributes to growth directionality.

Zhuang L, et al. (2007 Mar). Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans.

Fischer R, et al. (2008 May). Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Zhang J, et al. (2009 Dec 11). Dynein light intermediate chain in Aspergillus nidulans is essential for the interaction between heavy and intermediate chains.

Abenza JF, et al. (2009 Jan). Long-distance movement of Aspergillus nidulans early endosomes on microtubule tracks.

Zekert N, et al. (2009 Jan). The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules.

Zhang J, et al. (2010 Oct 15). The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation.

Zhang J, et al. (2011 Jun 27). The p25 subunit of the dynactin complex is required for dynein-early endosome interaction.

Egan MJ, et al. (2012 Dec). Microtubule-based transport in filamentous fungi.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

Etxebeste O, et al. (2013). Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells.

Qiu R, et al. (2013 Jan 25). Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.

Egan MJ, et al. (2015 Apr 14). Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 23 genes with posterior transmembrane prediction > 50%