FOG15744
EOG8B5MP0

sce:ECM2

Genes: 31

SGD Description
Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p


PomBase Description
RNA-binding protein Cwf5


AspGD Description
Ortholog(s) have Prp19 complex, spliceosomal complex localization


References

Xu D, et al. (1998 Apr). Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.

McDonald WH, et al. (1999 Aug). Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing.

Xu D, et al. (2001 Feb). Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome.

Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Ohi MD, et al. (2002 Jun). Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.

Carnahan RH, et al. (2005 Mar). Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Livesay SB, et al. (2013 Nov). Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Bayne EH, et al. (2014). A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Kallgren SP, et al. (2014). The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen W, et al. (2014 Mar). Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%