FOG15735
EOG8B5MPK

sce:RPN12

Genes: 32

SGD Description
Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress


PomBase Description
19S proteasome regulatory subunit Rpn12


AspGD Description
Ortholog(s) have role in proteasome-mediated ubiquitin-dependent protein catabolic process and CENP-A containing chromatin, nucleus, proteasome regulatory particle, lid subcomplex, proteasome storage granule localization


References

Nisogi H, et al. (1992 May). A new essential gene of Saccharomyces cerevisiae, a defect in it may result in instability of nucleus.

Kominami K, et al. (1995 Jul 3). Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%