FOG15696
EOG8B8GZ6

sce:PUP3

Genes: 33

SGD Description
Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10


PomBase Description
20S proteasome complex subunit beta 3, Pup3 (predicted)


AspGD Description
Ortholog(s) have endopeptidase activator activity and role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process


References

Basile G, et al. (1992 Jul). Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.

Groll M, et al. (1997 Apr 3). Structure of 20S proteasome from yeast at 2.4 A resolution.

Groll M, et al. (2000 Nov). A gated channel into the proteasome core particle.

Whitby FG, et al. (2000 Nov 2). Structural basis for the activation of 20S proteasomes by 11S regulators.

Groll M, et al. (2006 Apr 19). Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

Groll M, et al. (2006 Jun). TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.

Groll M, et al. (2006 Mar). Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%