FOG15674
EOG8BCC3F

sce:SDP1;MSG5

Genes: 31

SGD Description
Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication|Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p; MSG5 has a paralog, SDP1, that arose from the whole genome duplication


PomBase Description
dual-specificity MAP kinase phosphatase Pmp1


AspGD Description
Ortholog(s) have role in regulation of spore germination


References

Séraphin B, et al. (1985). Primary structure of a gene for subunit V of the cytochrome c oxidase from Saccharomyces cerevisiae.

Doi K, et al. (1994 Jan 1). MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.

Csank C, et al. (1997 Dec). Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.

Csank C, et al. (1998 Jun). Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.

Guhad FA, et al. (1998 Nov). Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis model.

Schröppel K, et al. (2000 Dec). Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p.

Collister M, et al. (2002 Sep 11). YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Fox GC, et al. (2007 May 24). Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Blankenship JR, et al. (2010 Feb 5). An extensive circuitry for cell wall regulation in Candida albicans.

de Assis LJ, et al. (2015 Mar 11). Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%