FOG15642
EOG8BG7CC

sce:MTH1;STD1

Genes: 22

SGD Description
Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication|Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication


References

Ganster RW, et al. (1993 Jun). Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein.

Hubbard EJ, et al. (1994 Mar). Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae.

Schmidt MC, et al. (1999 Jul). Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae.

Kuchin S, et al. (2003 Feb). Std1p (Msn3p) positively regulates the Snf1 kinase in Saccharomyces cerevisiae.

Brown JC, et al. (2009 Oct 1). A heritable switch in carbon source utilization driven by an unusual yeast prion.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%