FOG15604
EOG8BK3K3

sce:MDN1

Genes: 32

SGD Description
Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus


PomBase Description
midasin (predicted)


AspGD Description
Ortholog(s) have role in rRNA processing, ribosomal large subunit assembly and mitochondrion, mitotic spindle pole body, nucleoplasm, preribosome, large subunit precursor localization


References

Bassler J, et al. (2001 Sep). Identification of a 60S preribosomal particle that is closely linked to nuclear export.

Garbarino JE, et al. (2002 Jul 8). Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein.

Nissan TA, et al. (2002 Oct 15). 60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm.

Galani K, et al. (2004 Dec 31). Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits.

Nissan TA, et al. (2004 Jul 23). A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits.

Ulbrich C, et al. (2009 Sep 4). Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits.

Bassler J, et al. (2010 Jun 11). The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly.

Matsuo Y, et al. (2014 Jan 2). Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.

Barrio-Garcia C, et al. (2016 Jan). Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%