FOG15578
EOG8BK3PG

sce:SEC11

Genes: 33

SGD Description
18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p


PomBase Description
signal peptidase subunit Sec11 (predicted)


AspGD Description
Putative signal peptidase complex subunit; expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Böhni PC, et al. (1988 Apr). SEC11 is required for signal peptide processing and yeast cell growth.

YaDeau JT, et al. (1989 Feb 15). Solubilization and characterization of yeast signal peptidase.

YaDeau JT, et al. (1991 Jan 15). Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.

Mullins C, et al. (1995 Jul 21). A mutation affecting signal peptidase inhibits degradation of an abnormal membrane protein in Saccharomyces cerevisiae.

Meyer HA, et al. (1997 May 16). The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity.

VanValkenburgh C, et al. (1999 Apr 23). The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases.

Chen X, et al. (2001 Jan 26). Signal peptidase and oligosaccharyltransferase interact in a sequential and dependent manner within the endoplasmic reticulum.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Ravin NV, et al. (2013 Nov 27). Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 26 genes with posterior transmembrane prediction > 50%