FOG15555
EOG8BNZTM

sce:DPH1

Genes: 33

SGD Description
Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p


PomBase Description
diphthamide biosynthesis protein Dph1 (predicted)


AspGD Description
Ortholog(s) have role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytosol, nucleus localization


References

Fichtner L, et al. (2003 Sep). Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

Liu S, et al. (2004 Nov). Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%