FOG15529
EOG8BNZZZ

sce:URM1

Genes: 30

SGD Description
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response


PomBase Description
ubiquitin family protein Urm1 (predicted)


References

Furukawa K, et al. (2000 Mar 17). A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes.

Goehring AS, et al. (2003 Nov). Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast.

Goehring AS, et al. (2003 Oct). Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p.

Xu J, et al. (2006 Aug 1). Solution structure of Urm1 and its implications for the origin of protein modifiers.

Schmitz J, et al. (2008 Jun 17). The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.

Yu J, et al. (2008 May 1). Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae.

Schlieker CD, et al. (2008 Nov 25). A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

Huang B, et al. (2008 Oct). A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.

Nakai Y, et al. (2008 Oct 10). Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems.

Noma A, et al. (2009 Mar). Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.

Leidel S, et al. (2009 Mar 12). Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.

Van der Veen AG, et al. (2011 Feb 1). Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%