FOG15463
EOG8BVQF2

sce:FIS1

Genes: 34

SGD Description
Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation


PomBase Description
mitochondrial fission protein Fis1 (predicted)


AspGD Description
Ortholog(s) have role in chronological cell aging, hyphal growth, mitochondrial fission, peroxisome fission and mitochondrial outer membrane, peroxisome localization


References

Mozdy AD, et al. (2000 Oct 16). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.

Tieu Q, et al. (2000 Oct 16). Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division.

Tieu Q, et al. (2002 Aug 5). The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission.

Beilharz T, et al. (2003 Mar 7). Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae.

Jakobs S, et al. (2003 May 15). Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Cerveny KL, et al. (2003 Oct). The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Suzuki M, et al. (2005 Jun 3). Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Koirala S, et al. (2013 Apr 9). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Delerue T, et al. (2016 Oct). Loss of Msp1p in Schizosaccharomyces pombe induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%