FOG15430
EOG8BZKMJ

sce:PRP45

Genes: 32

SGD Description
Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene


PomBase Description
splicing factor Prp45


AspGD Description
Ortholog(s) have role in mRNA cis splicing, via spliceosome and Prp19 complex, mitotic spindle pole body, spliceosomal complex localization


References

Ambrozková M, et al. (2001 Jun 29). The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF.

Skruzný M, et al. (2001 Oct 31). Cyclophilins of a novel subfamily interact with SNW/SKIP coregulator in Dictyostelium discoideum and Schizosaccharomyces pombe.

Ohi MD, et al. (2002 Apr). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.

Martinkova K, et al. (2002 Oct). Functional mapping of Saccharomyces cerevisiae Prp45 identifies the SNW domain as essential for viability.

Albers M, et al. (2003 Jan). Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors.

Carnahan RH, et al. (2005 Mar). Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Grenier St-Sauveur V, et al. (2013 Dec). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Livesay SB, et al. (2013 Nov). Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Bayne EH, et al. (2014). A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Kallgren SP, et al. (2014). The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen W, et al. (2014 Mar). Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%