FOG15427
EOG8BZKN3

sce:DCP1

Genes: 25

SGD Description
Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress


References

Beelman CA, et al. (1996 Aug 15). An essential component of the decapping enzyme required for normal rates of mRNA turnover.

Hatfield L, et al. (1996 Oct). Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.

Anderson JS, et al. (1998 Mar 2). The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.

LaGrandeur TE, et al. (1998 Mar 2). Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme.

Tharun S, et al. (1999 Apr). Analysis of mutations in the yeast mRNA decapping enzyme.

Schwartz DC, et al. (1999 Aug). Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.

Zhang S, et al. (1999 Jan). Monitoring mRNA decapping activity.

Muhlrad D, et al. (1999 Nov). Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.

Dunckley T, et al. (1999 Oct 1). The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.

Vilela C, et al. (2000 Aug 15). The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex.

Fromont-Racine M, et al. (2000 Jun 30). Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins.

Tharun S, et al. (2000 Mar 30). Yeast Sm-like proteins function in mRNA decapping and decay.

Coller JM, et al. (2001 Dec). The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.

Dunckley T, et al. (2001 Jan). Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.

Tharun S, et al. (2001 Nov). Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.

Fischer N, et al. (2002 Jun 3). The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.

Ramirez CV, et al. (2002 May 10). Modulation of eukaryotic mRNA stability via the cap-binding translation complex eIF4F.

Steiger M, et al. (2003 Feb). Analysis of recombinant yeast decapping enzyme.

Sheth U, et al. (2003 May 2). Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.

Holmes LE, et al. (2004 Apr). Loss of translational control in yeast compromised for the major mRNA decay pathway.

She M, et al. (2004 Mar). Crystal structure of Dcp1p and its functional implications in mRNA decapping.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Charenton C, et al. (2016 Nov). Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m⁷GDP and its Edc3 activator.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%