FOG15409
EOG8C2FS0

sce:VPS15

Genes: 33

SGD Description
Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery


PomBase Description
serine/threonine protein kinase Ppk19


AspGD Description
Ortholog(s) have role in pathogenesis, retrograde transport, endosome to Golgi


References

Robinson JS, et al. (1988 Nov). Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

Herman PK, et al. (1991 Dec). A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.

Herman PK, et al. (1991 Jan 25). A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole.

Vida TA, et al. (1993 Jun). Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.

Stack JH, et al. (1993 May). A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

Stack JH, et al. (1994 Dec 16). Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

Nothwehr SF, et al. (1996 Jun). The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins.

Kihara A, et al. (2001 Feb 5). Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Burda P, et al. (2002 Oct 15). Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Ma Y, et al. (2010 Sep). Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.

Araki Y, et al. (2013 Oct 28). Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 24 genes with posterior transmembrane prediction > 50%