FOG15397
EOG8C2FV4

sce:NUC1

Genes: 33

SGD Description
Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG


PomBase Description
mitochondrial endodeoxyribonuclease Pnu1


AspGD Description
Ortholog(s) have endoribonuclease activity, exodeoxyribonuclease activity, single-stranded DNA endodeoxyribonuclease activity


References

Vincent RD, et al. (1988 Apr 25). Sequence and expression of NUC1, the gene encoding the mitochondrial nuclease in Saccharomyces cerevisiae.

Liu YX, et al. (1989 Aug). Overproduction of yeast viruslike particles by strains deficient in a mitochondrial nuclease.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

de Castro Pimentel Figueiredo B, et al. (2011 Feb). The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.

Dinamarco TM, et al. (2011 Oct). Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%