FOG15374
EOG8C5B0S

sce:ATG9

Genes: 34

SGD Description
Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS


PomBase Description
autophagy associated protein Atg9


AspGD Description
Transmembrane protein; predicted role in autophagy


References

Tsukada M, et al. (1993 Oct 25). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Harding TM, et al. (1995 Nov). Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.

Harding TM, et al. (1996 Jul 26). Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway.

Lang T, et al. (2000 Apr). Autophagy and the cvt pathway both depend on AUT9.

Noda T, et al. (2000 Feb 7). Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways.

Wang CW, et al. (2001 Aug 10). Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.

Suzuki K, et al. (2001 Nov 1). The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.

Tucker KA, et al. (2003 Nov 28). Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy.

Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.

Reggiori F, et al. (2004 Jan). The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.

Shintani T, et al. (2004 Jul 16). Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.

Reggiori F, et al. (2005 Jul). Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts.

He C, et al. (2006 Dec 18). Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast.

Reggiori F, et al. (2006 Jul 15). Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Bernales S, et al. (2006 Nov). Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response.

Suzuki K, et al. (2007 Feb). Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Yen WL, et al. (2007 Feb). Atg27 is required for autophagy-dependent cycling of Atg9.

Palmer GE, et al. (2007 Jan). Autophagy in the pathogen Candida albicans.

Chang CY, et al. (2007 Mar). Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy.

He C, et al. (2007 May-Jun). Atg9 trafficking in autophagy-related pathways.

Legakis JE, et al. (2007 Sep-Oct). A cycling protein complex required for selective autophagy.

He C, et al. (2008 Dec). Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy.

Geng J, et al. (2008 Jul 14). Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy.

Monastyrska I, et al. (2008 May). Arp2 links autophagic machinery with the actin cytoskeleton.

Kanki T, et al. (2008 Nov 21). Mitophagy in yeast occurs through a selective mechanism.

Sekito T, et al. (2009 May). Atg17 recruits Atg9 to organize the pre-autophagosomal structure.

Yen WL, et al. (2010 Jan 11). The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.

Geng J, et al. (2010 Jul 1). Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae.

van der Vaart A, et al. (2010 Jul 1). Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae.

Ohashi Y, et al. (2010 Nov 15). Membrane delivery to the yeast autophagosome from the Golgi-endosomal system.

Mari M, et al. (2010 Sep 20). An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis.

Bruns C, et al. (2011 Dec 12). Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion.

Nair U, et al. (2011 Jul 22). SNARE proteins are required for macroautophagy.

Mao K, et al. (2011 May 16). Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae.

Kakuta S, et al. (2012 Dec 28). Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site.

Yamamoto H, et al. (2012 Jul 23). Atg9 vesicles are an important membrane source during early steps of autophagosome formation.

Lipatova Z, et al. (2012 May 1). Regulation of selective autophagy onset by a Ypt/Rab GTPase module.

Umekawa M, et al. (2012 May 11). Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway.

Wang K, et al. (2012 Nov 2). Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.

Suzuki K, et al. (2013 Jun 1). Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.

Papinski D, et al. (2014 Jul). Atg1 kinase organizes autophagosome formation by phosphorylating Atg9.

Yao Z, et al. (2015). Atg41/Icy2 regulates autophagosome formation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%