FOG15313
EOG8C86B8

sce:ATG4

Genes: 34

SGD Description
Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation


PomBase Description
Atg8 deconjugator Atg4 (predicted)


AspGD Description
Cysteine protease; predicted role in autophagic vacuole assembly


References

Tsukada M, et al. (1993 Oct 25). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Thumm M, et al. (1994 Aug 1). Isolation of autophagocytosis mutants of Saccharomyces cerevisiae.

Lang T, et al. (1998 Jul 1). Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole.

Ichimura Y, et al. (2000 Nov 23). A ubiquitin-like system mediates protein lipidation.

Kirisako T, et al. (2000 Oct 16). The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway.

Kim J, et al. (2001 Jan 8). Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex.

Krampe S, et al. (2002 Feb 27). Starvation-induced degradation of yeast hexose transporter Hxt7p is dependent on endocytosis, autophagy and the terminal sequences of the permease.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Amar N, et al. (2006 Jun). Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy.

Nakatogawa H, et al. (2007 Jul 13). Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.

Cao Y, et al. (2008 Aug 25). In vivo reconstitution of autophagy in Saccharomyces cerevisiae.

Krick R, et al. (2008 Oct). Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.

Ecker N, et al. (2010 Oct). Induction of autophagic flux by amino acid deprivation is distinct from nitrogen starvation-induced macroautophagy.

Nakatogawa H, et al. (2012 Feb 1). Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.

Yu ZQ, et al. (2012 Jun). Dual roles of Atg8-PE deconjugation by Atg4 in autophagy.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%