FOG15225
EOG8CFXSN

sce:RTT106

Genes: 32

SGD Description
Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)


PomBase Description
histone chaperone Rtt106-like (predicted)


AspGD Description
Ortholog(s) have double-stranded DNA binding, histone binding activity


References

Scholes DT, et al. (2001 Dec). Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance.

Huang S, et al. (2005 Sep 20). Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing.

Huang S, et al. (2007 May 2). A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing.

Fillingham J, et al. (2009 Aug 14). Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression.

Burgess RJ, et al. (2010 Feb 26). A role for Gcn5 in replication-coupled nucleosome assembly.

Liu Y, et al. (2010 Feb 5). Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing.

Ferreira ME, et al. (2011). The Saccharomyces cerevisiae histone chaperone Rtt106 mediates the cell cycle recruitment of SWI/SNF and RSC to the HIR-dependent histone genes.

Wan Y, et al. (2011 Aug 4). Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing.

Kurat CF, et al. (2011 Dec 1). Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein.

Yu Y, et al. (2011 Jun). A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast.

Su D, et al. (2012 Feb 5). Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.

Amin AD, et al. (2012 Jan). The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.

Silva AC, et al. (2012 Jan 13). The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.

Zunder RM, et al. (2012 Jan 17). Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%