FOG15113
EOG8CRJFG

sce:NDC80

Genes: 29

SGD Description
Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation


PomBase Description
NMS complex subunit Ndc80


AspGD Description
Ortholog(s) have structural constituent of cytoskeleton activity


References

Rout MP, et al. (1990 Nov). Components of the yeast spindle and spindle pole body.

Dresser ME, et al. (1997 Oct). DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.

Wigge PA, et al. (1998 May 18). Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

Zheng L, et al. (1999 Aug). Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins.

Janke C, et al. (2001 Feb 15). The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control.

Wigge PA, et al. (2001 Jan 22). The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.

Chen Y, et al. (2002 Dec 20). Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.

Le Masson I, et al. (2002 Mar). Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication.

McCleland ML, et al. (2003 Jan 1). The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

Kerres A, et al. (2004 Dec). The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.

Yang L, et al. (2004 Oct). Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in Aspergillus nidulans.

Wei RR, et al. (2005 Apr 12). Molecular organization of the Ndc80 complex, an essential kinetochore component.

De Souza CP, et al. (2009 Apr). Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%