FOG15036
EOG8CZ8XS

sce:RFA1

Genes: 34

SGD Description
Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia


PomBase Description
DNA replication factor A subunit Ssb1


AspGD Description
Ortholog(s) have single-stranded DNA binding activity and role in DNA repair, mitotic DNA replication, premeiotic DNA replication, telomere maintenance


References

Nasim A, et al. (1975 Apr). Genetic control of radiation sensitivity in Schizosaccharomyces pombe.

Heyer WD, et al. (1990 Jul). An essential Saccharomyces cerevisiae single-stranded DNA binding protein is homologous to the large subunit of human RP-A.

Brill SJ, et al. (1991 Sep). Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase.

Luche RM, et al. (1993 Sep). Saccharomyces cerevisiae BUF protein binds to sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation.

Clark MW, et al. (1994 Apr). Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region.

Ishiai M, et al. (1996 Aug 23). Purification, gene cloning, and reconstitution of the heterotrimeric single-stranded DNA-binding protein from Schizosaccharomyces pombe.

Parker AE, et al. (1997 May). The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A.

Perego P, et al. (1998 Jul). Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.

Suto K, et al. (1999 Oct). A double-strand break repair component is essential for S phase completion in fission yeast cell cycling.

Forsburg SL, et al. (2000 Jul). Mitotic replication initiation proteins are not required for pre-meiotic S phase.

Tsutsui Y, et al. (2001 Sep). Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.

Ono Y, et al. (2003 Dec 15). A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

VanDemark AP, et al. (2006 May 5). The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.

Kibe T, et al. (2007 Jun). Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.

Limbo O, et al. (2007 Oct 12). Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Moser BA, et al. (2009 Apr 8). Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Subramanian L, et al. (2010 Feb 5). A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.

Cavero S, et al. (2010 Sep 23). Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Akai Y, et al. (2011 Dec). Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Luciano P, et al. (2012 Apr 18). RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Saito Y, et al. (2013). The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.

Yu Y, et al. (2013 Jun 1). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Murayama Y, et al. (2013 Nov 1). Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Ding L, et al. (2014 May 28). Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Audry J, et al. (2015 Jul 14). RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.

Zeng M, et al. (2016 Apr 21). CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.

Zhang H, et al. (2016 Nov 25). Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks.

McDonald KR, et al. (2016 Sep). Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

Iyer DR, et al. (2017 Aug). Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA.

Manjón E, et al. (2017 May 19). Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%