FOG14911
EOG8D7WPJ

sce:TOM40

Genes: 33

SGD Description
Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions


PomBase Description
mitochondrial TOM complex subunit Tom40 (predicted)


AspGD Description
Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in conidium formation, hyphal growth, protein import into mitochondrial matrix, protein import into mitochondrial outer membrane


References

Baker KP, et al. (1990 Dec 13). A yeast mitochondrial outer membrane protein essential for protein import and cell viability.

Dekker PJ, et al. (1998 Nov). Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex.

Rapaport D, et al. (1999 Jul 26). Biogenesis of Tom40, core component of the TOM complex of mitochondria.

von der Malsburg K, et al. (2011 Oct 18). Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%