FOG14887
EOG8DBRW3

sce:ELP3

Genes: 33

SGD Description
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin


PomBase Description
elongator complex subunit Elp3 (predicted)


AspGD Description
Ortholog(s) have histone acetyltransferase activity, role in regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex, cytosol, nucleus localization


References

Otero G, et al. (1999 Jan). Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Wittschieben BO, et al. (1999 Jul). A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme.

Frohloff F, et al. (2001 Apr 17). Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

Winkler GS, et al. (2001 Aug 31). RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.

Krogan NJ, et al. (2001 Dec). Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.

Winkler GS, et al. (2002 Mar 19). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Klassen R, et al. (2003 Nov). Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora.

Petrakis TG, et al. (2004 Jul 30). Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator.

Huang B, et al. (2005 Apr). An early step in wobble uridine tRNA modification requires the Elongator complex.

Rahl PB, et al. (2005 Mar 18). Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.

Petrakis TG, et al. (2005 May 20). Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.

Paraskevopoulou C, et al. (2006 Feb). The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine.

Nützmann HW, et al. (2011 Aug 23). Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%