FOG14844
EOG8DFN56

sce:KAE1

Genes: 33

SGD Description
Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription


PomBase Description
EKC/KEOPS complex ATPase subunit Pgp2


AspGD Description
Ortholog(s) have chromatin DNA binding activity and role in positive regulation of transcription from RNA polymerase II promoter, tRNA modification, tRNA threonylcarbamoyladenosine metabolic process, telomere maintenance via recombination


References

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Lopreiato R, et al. (2004 Jan 15). Analysis of the interaction between piD261/Bud32, an evolutionarily conserved protein kinase of Saccharomyces cerevisiae, and the Grx4 glutaredoxin.

Kisseleva-Romanova E, et al. (2006 Aug 9). Yeast homolog of a cancer-testis antigen defines a new transcription complex.

Downey M, et al. (2006 Mar 24). A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Daugeron MC, et al. (2011 Aug). Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.

El Yacoubi B, et al. (2011 Mar 2). A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification.

Srinivasan M, et al. (2011 Mar 2). The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.

Perrochia L, et al. (2013 Feb 1). In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya.

Wan LC, et al. (2013 Jul). Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Dzikowska A, et al. (2015 Dec 1). KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%