FOG14812
EOG8DJHBJ

sce:IRE1

Genes: 35

SGD Description
Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress


PomBase Description
serine/threonine protein kinase, sensor for unfolded proteins in the ER Ire1


AspGD Description
Ortholog(s) have endoribonuclease activity, protein homodimerization activity, protein serine/threonine kinase activity, unfolded protein binding activity


References

Nikawa J, et al. (1992 Jun). IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae.

Mori K, et al. (1993 Aug 27). A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus.

Welihinda AA, et al. (1996 Jul 26). The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation.

Shamu CE, et al. (1996 Jun 17). Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

Sidrauski C, et al. (1997 Sep 19). The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%