FOG14800
EOG8DJHCT

sce:CLP1

Genes: 33

SGD Description
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription


PomBase Description
mRNA cleavage and polyadenylation specificity factor complex subunit (predicted)


AspGD Description
Protein similar to cleavage/polyadenylation factor IA subunit CLP1


References

Heimberg H, et al. (1990 May 31). Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase.

Kessler MM, et al. (1996 Oct 25). Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends.

Minvielle-Sebastia L, et al. (1997 Jul 22). The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation.

Gross S, et al. (2001 May 22). Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.

Noble CG, et al. (2007). Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.

Ramirez A, et al. (2008 Sep). Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo.

Holbein S, et al. (2011). The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation.

Gordon JM, et al. (2011 Nov 29). Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology.

Ghazy MA, et al. (2012 Feb). The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.

Haddad R, et al. (2012 Feb). An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%