FOG14756
EOG8DNCN7

sce:VTA1

Genes: 5

SGD Description
Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain


References

Thomas D, et al. (1987 Dec 5). SAM1, the structural gene for one of the S-adenosylmethionine synthetases in Saccharomyces cerevisiae. Sequence and expression.

Yeo SC, et al. (2003 Oct 1). Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.

Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Shiflett SL, et al. (2004 Mar 19). Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae.

Lottridge JM, et al. (2006 Apr 18). Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body.

Azmi I, et al. (2006 Feb 27). Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.

Rue SM, et al. (2008 Feb). Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting.

Azmi IF, et al. (2008 Jan). ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1.

Xiao J, et al. (2008 Jan). Structural basis of Vta1 function in the multivesicular body sorting pathway.

Yu Z, et al. (2008 Mar 21). Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%