FOG14736
EOG8DR7T5

sce:THO2

Genes: 33

SGD Description
Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids


PomBase Description
THO complex subunit Tho2 (predicted)


AspGD Description
Protein of unknown function|Protein of unknown function


References

Piruat JI, et al. (1998 Aug 17). A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.

West RW Jr, et al. (2000 Feb 8). RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN4.

Chávez S, et al. (2000 Nov 1). A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.

Jimeno S, et al. (2002 Jul 1). The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.

Strässer K, et al. (2002 May 16). TREX is a conserved complex coupling transcription with messenger RNA export.

Rondón AG, et al. (2003 Oct 3). Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.

Huertas P, et al. (2003 Sep). Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.

Abruzzi KC, et al. (2004 Jul 7). Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 19 genes with posterior transmembrane prediction > 50%