FOG14715
EOG8DR7X8

sce:ELP4

Genes: 32

SGD Description
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity


PomBase Description
elongator complex subunit Elp4 (predicted)


AspGD Description
Ortholog(s) have ATPase activity, tRNA binding activity, role in regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex, cytosol, nucleus localization


References

Otero G, et al. (1999 Jan). Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Frohloff F, et al. (2001 Apr 17). Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

Li Y, et al. (2001 Aug 10). A multiprotein complex that interacts with RNA polymerase II elongator.

Winkler GS, et al. (2001 Aug 31). RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.

Krogan NJ, et al. (2001 Dec). Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.

Winkler GS, et al. (2002 Mar 19). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Klassen R, et al. (2003 Nov). Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora.

Petrakis TG, et al. (2004 Jul 30). Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator.

Huang B, et al. (2005 Apr). An early step in wobble uridine tRNA modification requires the Elongator complex.

Rahl PB, et al. (2005 Mar 18). Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.

Petrakis TG, et al. (2005 May 20). Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Bauer F, et al. (2012 May 31). Translational control of cell division by Elongator.

Fernández-Vázquez J, et al. (2013). Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Gaspa L, et al. (2016). A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%