FOG14655
EOG8DZ092

sce:SSK22;SSK2

Genes: 36

SGD Description
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication|MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication


PomBase Description
MAP kinase kinase kinase Win1|MAP kinase kinase kinase Wis4


AspGD Description
Ortholog(s) have MAP kinase kinase kinase activity


References

Maeda T, et al. (1995 Jul 28). Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

Furukawa K, et al. (2005 Jun). Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Ma D, et al. (2013 Feb). Current understanding of HOG-MAPK pathway in Aspergillus fumigatus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%