FOG14637
EOG8DZ0DJ

sce:TGS1

Genes: 33

SGD Description
Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p


PomBase Description
rRNA methyltransferase Tgs1 (predicted)


AspGD Description
Ortholog(s) have RNA trimethylguanosine synthase activity and role in 7-methylguanosine cap hypermethylation, meiotic nuclear division, nucleologenesis, regulation of telomere maintenance via telomerase


References

Mouaikel J, et al. (2002 Apr). Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus.

Mouaikel J, et al. (2003 Aug 15). Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase.

Colau G, et al. (2004 Sep). The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.

Hausmann S, et al. (2005 Feb 11). Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).

Hausmann S, et al. (2007). Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.

Franke J, et al. (2008 Nov 1). Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.

Hausmann S, et al. (2008 Nov 14). Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Lee NN, et al. (2013 Nov 21). Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Borg RM, et al. (2016 Oct). Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%